################################################################################################
# Program: MUSTANG-Lite v0.1: A Multiple structural alignment algorithm
# Authors: A. S. Konagurthu, A. M. Lesk, J. C. Whisstock, and P. J. Stuckey
# Rundate: Fri Aug 12 22:38:25 2005
# Report_file: /mnt/EXTRA_STORAGE/MUSTANG_RESULTS/MUSTANG_HOMSTRAD/results/kinase.html
################################################################################################
#====================================
# Aligned_structures: 15
# 1: 1a06.pdb
# 2: 1a6o.pdb
# 3: 1b6cb.pdb
# 4: 1blxa.pdb
# 5: 1cdka.pdb
# 6: 1ckia.pdb
# 7: 1csn.pdb
# 8: 1hcl.pdb
# 9: 1jnk.pdb
# 10: 1koa.pdb
# 11: 1koba.pdb
# 12: 1p38.pdb
# 13: 1phk.pdb
# 14: 1tkia.pdb
# 15: 3erk.pdb
#
# Length: 646
# Identity: 8/646 ( 1.2%) (Calculated as the percentage of conserved columns in the alignment.)
# Similarity: 11/646 ( 1.7%) (Calculated as the percentage of semi-conserved columns in the alignment)
# Gaps: 442/646 ( 68.4%) (Calculated as the percentage of columns with atleast one gap.)
#===========================================ALIGNMENT START=========================================
1a06.pdb 1 ---------------------------W-------------------------KQ----- 3
1a6o.pdb 1 -----SKARVY----ADVNV----LRPKEYWD-YEA-----L--------TVQ--WG--- 28
1b6cb.pdb 1 ----T----TL----KDLIY----DMT-TS-----G------------SG-SG---LPLL 22
1blxa.pdb ------------------------------------------------------------
1cdka.pdb 1 KG-------SEQESVKEFLA----KAKEDFLKKW-E-----N---------PAQNTA--- 31
1ckia.pdb 1 -------------------------------------------------M-------E-- 2
1csn.pdb ------------------------------------------------------------
1hcl.pdb ------------------------------------------------------------
1jnk.pdb 1 --------------------------------------DN--QFYSVEV-GDS---T--- 13
1koa.pdb 1 ----------Y----DNYV-FDIWKQYY------------PQ-------P-VEIK----- 20
1koba.pdb 1 ---IN----DY----DKFY-EDIWKKYV------------PQ-------P-VEVK----- 23
1p38.pdb 1 --------------------------------------ER-PTFYRQEL-NKT---I--- 14
1phk.pdb ------------------------------------------------------------
1tkia.pdb 1 --K--------------------------------------------------------- 1
3erk.pdb 1 ------------------------------------AA------GPEMV-RGQ---V--- 11
1a06.pdb 4 ------AED---IRDIYDFRDVLGTGA-FS-EVILAEDKRT-QKLVAIKCIAK------- 44
1a6o.pdb 29 --------E----QDDYEVVRKVGRG-KY-SEVFEGINVNN-NEKCIIKILKP------- 66
1b6cb.pdb 23 VQR-----TI---ARTIVLQESIGKG-RF-GEVWRGKWR---GEEVAVKIFSS------- 62
1blxa.pdb 1 -----GLCR---ADQQYECVAEIGEG-AY-GKVFKARDLKNGGRFVALKRVRV-QTGEE- 48
1cdka.pdb 32 --------H----LDQFERIKTLGTG-SF-GRVMLVKHKET-GNHFAMKILDK------- 69
1ckia.pdb 3 ----------LRVGNRYRLGRKIGSG-SF-GDIYLGTDIAA-GEEVAIKLECV------- 42
1csn.pdb 1 ----------NVVGVHYKVGRRIGEG-SF-GVIFEGTNLLN-NQQVAIKFEPR------- 40
1hcl.pdb 1 -------------MENFQKVEKIGEG-TY-GVVYKARNKLT-GEVVALKKIR-------T 37
1jnk.pdb 14 ---FT-------VLKRYQNLKPIGSG-AQ-GIVCAAYDAVL-DRNVAIKKLSRPF----- 55
1koa.pdb 21 ------HDH---VLDHYDIHEELGTG-AF-GVVHRVTERAT-GNNFAAKFVMT------- 61
1koba.pdb 24 ------QGS---VYDYYDILEELGSG-AF-GVVHRCVEKAT-GRVFVAKFINT------- 64
1p38.pdb 15 ---WE-------VPERYQNLSPVGSG-AY-GSVCAAFDTKT-GHRVAVKKLSRPF----- 56
1phk.pdb 1 ------------FYENYEPKEILGRG-VS-SVVRRCIHKPT-CKEYAVKIIDV------- 38
1tkia.pdb 2 --------E---LYEKYMIAEDLGRG-EF-GIVHRCVETSS-KKTYMAKFVKV------- 40
3erk.pdb 12 ---FD-------VGPRYTNLSYIGEG-AY-GMVCSAYDNLN-KVRVAIKKISP-F----- 52
G G K
1a06.pdb 45 -----------------------ENEIAVLHKI--KHPNIVALDDIYESG---------- 69
1a6o.pdb 67 --V---------KK---KKIKREIKILQNLC----GGPNIVKLLDIVRDQ-H----S--- 100
1b6cb.pdb 63 --R---------E------ERSWFREAEIYQTVMLRHENILGFIAADNKD-NG---T--W 99
1blxa.pdb 49 GM----------PL---STIREVAV-LRHLETF--EHPNVVRLFDVCTVSRT-----DRE 87
1cdka.pdb 70 --Q---------KVVKLKQIEHTLNEKRILQAV--NFPFLVKLEYSFKDN---------- 106
1ckia.pdb 43 --K---------T----K-HPQLHIESKIYKMM-QGGVGIPTIRWCGAEG---------- 75
1csn.pdb 41 --R---------S----D-APQLRDEYRTYKLL-AGCTGIPNVYYFGQEG---------- 73
1hcl.pdb 38 EGV---------PS---TAIRE----ISLLKEL--NHPNIVKLLDVIHTEN--------- 70
1jnk.pdb 56 --Q---------NQ---THAKRAYRELVLMKCV--NHKNIISLLNVFTPQKT-LEEF--- 95
1koa.pdb 62 --P---------HE---SDKETVRKEIQTMSVL--RHPTLVNLHDAFEDD---------- 95
1koba.pdb 65 --P---------YP---LDKYTVKNEISIMNQL--HHPKLINLHDAFEDK---------- 98
1p38.pdb 57 --Q---------SI---IHAKRTYRELRLLKHM--KHENVIGLLDVFTPARS-LEEF--- 96
1phk.pdb 39 --TGGGSFSAEEVQ---ELREATLKEVDILRKV-SGHPNIIQLKDTYETN---------- 82
1tkia.pdb 41 --K----------G---TDQVLVKKEISILNIA--RHRNILHLHESFESM---------- 73
3erk.pdb 53 --E---------HQ---TYCQRTLREIKILLRF--RHENIIGINDIIR-APT-IEQM--- 91
1a06.pdb 70 GHLYLIMQLV-SGGE-LFDRIVEK--G--FYTERDASRLIFQVLDAVKYLHDL------- 116
1a6o.pdb 101 KTPSLIFEYV-N-NTDFKVLYP-------TLTDYDIRYYIYELLKALDYCHSQ------- 144
1b6cb.pdb 100 TQLWLVSDYHEH-GS-LFDYLNRY-----TVTVEGMIKLALSTASGLAHLHMEIVGTQGK 152
1blxa.pdb 88 TKLTLVFEHV-D-QD-LTTYLDKV--PEPGVPTETIKDMMFQLLRGLDFLHSH------- 135
1cdka.pdb 107 SNLYMVMEYV-PGGE-MFSHLRRI--G--RFSEPHARFYAAQIVLTFEYLHSL------- 153
1ckia.pdb 76 DYNVMVMELL-G-PS-LEDLFNFC--S-RKFSLKTVLLLADQMISRIEYIHSK------- 122
1csn.pdb 74 LHNVLVIDLL-G-PS-LEDLLDLC--G-RKFSVKTVAMAAKQMLARVQSIHEK------- 120
1hcl.pdb 71 -KLYLVFEFL-H-QD-LKKFMDAS--ALTGIPLPLIKSYLFQLLQGLAFCHSH------- 117
1jnk.pdb 96 QDVYLVMELM-D-AN-LCQVIQ-M-----ELDHERMSYLLYQMLCGIKHLHSA------- 139
1koa.pdb 96 NEMVMIYEFM-SGGE-LFEKV-ADEHN--KMSEDEAVEYMRQVCKGLCHMHEN------- 143
1koba.pdb 99 YEMVLILEFL-SGGE-LFDRI-AAEDY--KMSEAEVINYMRQACEGLKHMHEH------- 146
1p38.pdb 97 NDVYLVTHLM-G-AD-LNNIVKCQ-----KLTDDHVQFLIYQILRGLKYIHSA------- 141
1phk.pdb 83 TFFFLVFDLM-KKGE-LFDYLTEK--V--TLSEKETRKIMRALLEVICALHKL------- 129
1tkia.pdb 74 EELVMIFEFI-SGLD-IFERI-NTSAF--ELNEREIVSYVHQVCEALQFLHSH------- 121
3erk.pdb 92 KDVYIVQDLM-E-TD-LYKLLKTQ-----HLSNDHICYFLYQILRGLKYIHSA------- 136
H
1a06.pdb 117 -GIVHRDLKPENLLYYSLD---EDSKIMISDF---------------------------- 144
1a6o.pdb 145 -GIMHRDVKPHNVMIDH-E----LRKLRLIDWGL-----AEFYH-P-G----K----EYN 183
1b6cb.pdb 153 PAIAHRDLKSKNILVKK------NGTCCIADLGL-----AVRHD-SATD---T----IDI 193
1blxa.pdb 136 -RVVHRDLKPQNILVTS------SGQIKLADFG-----LARIYS-F-Q-MAL--TSV--- 175
1cdka.pdb 154 -DLIYRDLKPENLLIDQ------QGYIQVTDFGF-----AKRVK-G------R-----T- 188
1ckia.pdb 123 -NFIHRDVKPDNFLMGL-G-KK-GNLVYIIDFGL-----AKKYRDARTH---Q----HIP 166
1csn.pdb 121 -SLVYRDIKPDNFLIGRPNSKN-ANMIYVVDFGM-----VKFYRDPVTK---Q----HIP 166
1hcl.pdb 118 -RVLHRDLKPQNLLINT------EGAIKLADFG-LARAFGVPVR--------TYTHE--- 158
1jnk.pdb 140 -GIIHRDLKPSNIVVKS------DCTLKILDFGLA----SFMMT----------P-Y--- 174
1koa.pdb 144 -NYVHLDLKPENIMFTTKR----SNELKLIDFGL-----TAHLD-P-K----Q----SVK 183
1koba.pdb 147 -SIVHLDIKPENIMCETKK----ASSVKIIDFGL-----ATKLN-P-D----E----IVK 186
1p38.pdb 142 -DIIHRDLKPSNLAVNE------DCELKILDFGL-----ARHTD----------D-EM-- 176
1phk.pdb 130 -NIVHRDLKPENILLDD------DMNIKLTDFGF-----SCQLD-P-G----E----KLR 167
1tkia.pdb 122 -NIGHFDIRPENIIYQTRR----SSTIKIIEFGQ-----ARQLK-P-G----D----NFR 161
3erk.pdb 137 -NVLHRDLKPSNLLLNT------TCDLKICDFGL-----ARVAD-P-D----H----DHT 174
D kp N d
1a06.pdb 145 -----------PGYVAPEVLAQ------K-P------YSKAVDCWSIGVIAYILLCG--- 177
1a6o.pdb 184 ------VRVASRYFKGPELLVD------LQD------YDYSLDMWSLGCMFAGMIFR--- 222
1b6cb.pdb 194 -A-PN-HRVGTKRYMAPEVLDD------S-INMKHFESFKRADIYAMGLVFWEIARRCSI 243
1blxa.pdb 176 --------VVTLWYRAPEVLLQ------S-S------YATPVDLWSVGCIFAEMFRR--- 211
1cdka.pdb 189 ----W-TLCGTPEYLAPEIILS------K-G------YNKAVDWWALGVLIYEMAAG--- 227
1ckia.pdb 167 -YRENKNLTGTARYASINTHLG------I-E------QSRRDDLESLGYVLMYFNLG--- 209
1csn.pdb 167 -YREKKNLSGTARYMSINTHLG------R-E------QSRRDDLEALGHVFMYFLRG--- 209
1hcl.pdb 159 --------VVTLWYRAPEILLG------CKY------YSTAVDIWSLGCIFAEMVTR--- 195
1jnk.pdb 175 --------VVTRYYRAPEVILG------M-G------YKENVDIWSVGCIMGEMVRH--- 210
1koa.pdb 184 ------VTTGTAEFAAPEVAEG------K-P------VGYYTDMWSVGVLSYILLSG--- 221
1koba.pdb 187 ------VTTATAEFAAPEIVDR------E-P------VGFYTDMWAIGVLGYVLLSG--- 224
1p38.pdb 177 -T--GY--VATRWYRAPEIMLN-----WM-H------YNQTVDIWSVGCIMAELLTG--- 216
1phk.pdb 168 ------EVCGTPSYLAPEIIECSMNDNHP-G------YGKEVDMWSTGVIMYTLLAG--- 211
1tkia.pdb 162 ------LLFTAPEYYAPEVHQH------D-V------VSTATDMWSLGTLVYVLLSG--- 199
3erk.pdb 175 GF--LTEYVATRWYRAPEIMLN------S-K-G----YTKSIDIWSVGCILAEMLSN--- 217
D G
1a06.pdb 178 -------Y-PPFY-------D-E----NDAKLFEQIL-KAEY------------------ 198
1a6o.pdb 223 -------KEPFFY-------G-H----DNHDQLVKIA-KV-----LGTDGLNVYLN---- 253
1b6cb.pdb 244 GGIHEDYQ-LPYYDLVPSD---P----SVEEMRKVVCEQKLRPNI--------------- 280
1blxa.pdb 212 -------K-PLFR-------G-S----SDVDQLGKIL-DV-----IGLP-GEEDWP-R-- 241
1cdka.pdb 228 -------Y-PPFF-------A-D----QPIQIYEKIV-SGKV------------------ 248
1ckia.pdb 210 -------S-LPWQ-----G---L----KYERISEKKM-ST-----P-------------- 229
1csn.pdb 210 -------S-LPWQ-----GLKAATNKQKYERIGEKKQ-ST-----P-------------- 236
1hcl.pdb 196 -------R-ALFP-------G-D----SEIDQLFRIF-RT-----LGTP-DEVV--WPGV 226
1jnk.pdb 211 -------K-ILFP-------G-R----DYIDQWNKVI-EQ-----LGTP-CPEFMK---- 239
1koa.pdb 222 -------L-SPFG-------G-E----NDDETLRNVK-SCDW------------------ 242
1koba.pdb 225 -------L-SPFA-------G-E----DDLETLQNVK-RCDW------------------ 245
1p38.pdb 217 -------R-TLFP-------G-T----DHIDQLKLIL-RL-----VGTP-GAELLK---- 245
1phk.pdb 212 -------S-PPFW-------H-R----KQMLMLRMIM-SGNY------------------ 232
1tkia.pdb 200 -------I-NPFL-------A-E----TNQQIIENIM-NAEY------------------ 220
3erk.pdb 218 -------R-PIFP-------G-K----HYLDQLNHIL-GI-----LGSP-SQEDLN---- 246
1a06.pdb 199 ------------------------EF-DSPYW----D-D------------I-SDSAKDF 215
1a6o.pdb 254 -KYRIELDPQ---LEALVGRHSRKPW--LKFMNADNQHL------------V-SPEAIDF 294
1b6cb.pdb 281 -------------------------PN--RWQ----S-C------------EALRVMAKI 296
1blxa.pdb 242 -DVA---L-----PRQAFHSKSAQPI--EKFV----T-D------------I-DELGKDL 272
1cdka.pdb 249 ------------------------RF-----P----S-H------------F-SSDLKDL 261
1ckia.pdb 230 -------------------------I--EVLC----K-G------------Y-PSEFATY 244
1csn.pdb 237 -------------------------L--RELC----A-G------------F-PEEFYKY 251
1hcl.pdb 227 TSMP---D-----YKPSFPKWARQDF--SKVV----P-P------------L-DEDGRSL 258
1jnk.pdb 240 -KLQ----PTVRNYVENRPKYAGLTF--PKLF----P-DSLFPADSEHNKLK-ASQARDL 286
1koa.pdb 243 ------------------------NM-DDSAF----S-G------------I-SEDGKDF 259
1koba.pdb 246 ------------------------EF-DEDAF----S-S------------V-SPEAKDF 262
1p38.pdb 246 -KIS---SESARNYIQSLAQMPKMNF--ANVF----I-G------------A-NPLAVDL 281
1phk.pdb 233 ------------------------QF-GSPEW----D-D------------Y-SDTVKDL 249
1tkia.pdb 221 ------------------------TF-DEEAF----K-E------------I-SIEAMDF 237
3erk.pdb 247 -CII---NLKARNYLLSLPHKNKVPW--NRLF----P-N------------A-DSKALDL 282
1a06.pdb 216 IRHLME-KDPEKR-FT-----CEQALQHPWIAG-D--TA-LDK-NIHQS----------- 252
1a6o.pdb 295 LDKLLR-YDHQER-LT-----ALEAMTHPYFQQ-V--------------------R---A 323
1b6cb.pdb 297 MRECWY-ANGAAR-LT-----ALRIKKT-LSQL-S-------------QQEG-------- 326
1blxa.pdb 273 LLKCLT-FNPAKR-IS-----AYSALSHPYFQD-L--------------------E---R 301
1cdka.pdb 262 LRNLLQ-VDLTKR-FGNLKDGVNDIKNHKWFAT-T--------------------D---W 295
1ckia.pdb 245 LNFCRSLRF--DDKPD-----YSYLRQL-FRNL-F-------------HRQGFSYDYVFD 282
1csn.pdb 252 MHYARNLAF--DATPD-----YDYLQGL-FSKV-L-------------ERLNTTEDENFD 289
1hcl.pdb 259 LSQMLH-YDPNKR-IS-----AKAALAHPFFQD-V--------------------T---K 287
1jnk.pdb 287 LSKMLV-IDPAKR-IS-----VDDALQHPYINV-W----------------Y---D---P 316
1koa.pdb 260 IRKLLL-ADPNTR-MT-----IHQALEHPWLTPGN--APGRDSQIPSSR----------- 299
1koba.pdb 263 IKNLLQ-KEPRKR-LT-----VHDALEHPWLKG-D--HSNLTSRIPSSR----------- 301
1p38.pdb 282 LEKMLV-LDSDKR-IT-----AAQALAHAYFAQ-Y----------------H---D---P 311
1phk.pdb 250 VSRFLV-VQPQKR-YT-----AEEALAHPFFQQ-Y------------------------- 276
1tkia.pdb 238 VDRLLV-KERKSR-MT-----ASEALQHPWLKQ-KIERV-STKVIRTLK----------- 277
3erk.pdb 283 LDKMLT-FNPHKR-IE-----VEQALAHPYLEQ-Y----------------Y---D---P 312
1a06.pdb 253 VSEQIKK----NFAK--------------------------------------------- 263
1a6o.pdb 324 ------------------------------------A---ENS----------------- 327
1b6cb.pdb ------------------------------------------------------------
1blxa.pdb 302 -C--------------KEN----------------------------------------- 305
1cdka.pdb 296 -IAIYQRKVEA---PFIPKFKGPGD---TSNFDD----------------YEEEEIRVSI 332
1ckia.pdb 283 ------------------------------------WNML----KFGASR---------- 292
1csn.pdb 290 ------------------------------------WNLL-------------------- 293
1hcl.pdb 288 -P--V-----------PHLR---------------------------------------- 293
1jnk.pdb 317 -AEVEA----P----P---P----Q---L-----------DER-E-----HTI------- 333
1koa.pdb 300 YTKIRDS----IKT----------------------K---YDAWP------EP------- 317
1koba.pdb 302 YNKIRQK----IKE----------------------K---YADWP------AP------- 319
1p38.pdb 312 -DDEPV----A----D---P-----Y-DQ------SF---ESR-D-----LLI------- 331
1phk.pdb ------------------------------------------------------------
1tkia.pdb 278 HRRYYHT----LIKK----------------------------DL------NM------- 292
3erk.pdb 313 -SDEPI----A----E---A-----PFKF-----DM----ELD-D-----LPK------- 333
1a06.pdb 264 ---------SKW----KQAFNAT--AVVRHM--------------- 279
1a6o.pdb ----------------------------------------------
1b6cb.pdb ----------------------------------------------
1blxa.pdb ----------------------------------------------
1cdka.pdb 333 NEK----CGKEFSEF------------------------------- 343
1ckia.pdb ----------------------------------------------
1csn.pdb ----------------------------------------------
1hcl.pdb 294 ------------------------------------L--------- 294
1jnk.pdb 334 ---E-EWKELIYKEVM---------N-------------------- 346
1koa.pdb 318 ----LPPLGRIS----NYSS-LRKHRPQEYS-IRDA-FWDRSEA-- 350
1koba.pdb 320 ----QPAIGRIA----NFSS-LRKHRPQEYQ-IYDS-YFDRKEAV- 353
1p38.pdb 332 ---D-EWKSLTYDEVI---------S--FVP-PPLD---------- 351
1phk.pdb 277 ---------------------------------------------V 277
1tkia.pdb 293 ----VVSAARIS----CGGA-IR--SQKGVS-VAKV-KVASI---- 321
3erk.pdb 334 ---E-KLKELIFEETA---------R--FQPG-------------- 350
#=========================================ALIGNMENT END=============================================
#LEGEND:
#
# Colours indicate the chemical nature of the amino acid;
# Red = small hydrophobic including aromatic,{A,F,I,L,M,P,V,W}
# Blue = Acidic,{D,E}
# Magenta = Basic,{K,R} and
# Green = Basic amino acids with hydroxyl groups and/or amine groups {C,G,H,N,Q,S,T,Y}.
#
# The "markup row" below each stretch of the multiple alignment is used to mark completely conserved
# residue (denoted in UPPERCASE) and semi-conserved reside ( denoted in lowercase) in a column of the alignment.
#
################################################EOF#################################################